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  • Title: Epidermal Langerhans cells in Actinic Prurigo: a comparison between lesional and non-lesional skin.
    Author: Calderón-Amador J, Flores-Langarica A, Silva-Sánchez A, Donis-Maturano L, Granados J, Vega-Memije E, Lacy-Niebla RM, Hojyo-Tomoka T, Dominguez-Soto L, Flores-Romo L.
    Journal: J Eur Acad Dermatol Venereol; 2009 Apr; 23(4):438-40. PubMed ID: 19335731.
    Abstract:
    BACKGROUND: Actinic Prurigo (AP) is a chronic pruritic dermatosis of unknown cause affecting sun exposed skin in defined ethnic groups with characteristic MHC alleles. However, the cutaneous dendritic cells have not been assessed. OBJECTIVE: To assess in situ the epidermal Langerhans Cell (LC) status in Actinic Prurigo. STUDY DESIGN: Fresh skin samples from three AP patients were used to evaluate in situ the epidermal LC, comparing lesional and non-lesional sites in each subject. SETTING: AP patients attending the Dermatology Department at the Hospital M. Gea-Gonzalez in Mexico city. METHODS: Lesional and non-lesional skin samples were taken from each subject to prepare both epidermal sheets and conventional tissue sections. Three markers restricted to LC in epidermis (CD1a, ATPase, MHC-II) were used to quantify the LC per area in epidermal sheets. RESULTS: Compared to non-lesional skin from the same subject, a significant reduction in the number of LC per area of epidermis was found in lesional skin; with any of the three markers evaluated. CONCLUSION: The frequency of epidermal LC decreases importantly in lesional skin from AP patients.
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