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  • Title: [Tobacco smoking and drug interactions].
    Author: Molden E, Spigset O.
    Journal: Tidsskr Nor Laegeforen; 2009 Mar 26; 129(7):632-3. PubMed ID: 19337332.
    Abstract:
    Tobacco smoking increases the turnover of many drugs due to induction of drug-metabolizing enzymes. Smokers therefore require higher doses of agents such as clozapine, olanzapine and theophylline than non- smokers. Enzyme induction declines after smoking cessation and without concomitant dose reduction there is an increased risk of adverse effects.
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