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  • Title: Inclusion complexes of fluorofenidone with beta-cyclodextrin and hydroxypropyl-beta-cyclodextrin.
    Author: Wang S, Ding Y, Yao Y.
    Journal: Drug Dev Ind Pharm; 2009 Jul; 35(7):808-13. PubMed ID: 19337873.
    Abstract:
    BACKGROUND: Fluorofenidone is a novel antifibrotic drug and its aqueous solubility is low. AIM: This study was to prepare and characterize inclusion complexes of fluorofenidone (AKF-PD) with beta-cyclodextrin (beta-CD) and hydroxypropyl-beta-cyclodextrin (HP-beta-CD). METHOD: The AKF-PD/cyclodextrins (CDs) inclusion complexes were prepared by coprecipitation and freeze-drying, respectively. The solubility enhancement of AKF-PD was evaluated by phase solubility method. Inclusion complexation in solid phase was studied by X-ray diffraction (XRD) and differential thermal analysis (DTA). The dissolution profiles of AKF-PD/CDs inclusion complexes were investigated and compared with those of their physical mixtures and AKF-PD alone. RESULTS: The phase solubility diagrams of AKF-PD with beta-CD and HP-beta-CD were of A(L)-types, and the solubility of AKF-PD could be increased by 51.5% for beta-CD at 0.014 M and 794.0% for HP-beta-CD at 0.254 M. The results from XRD and DTA suggested that AKF-PD could form inclusion complex with beta-CD or HP-beta-CD. The dissolution rate of AKF-PD from the inclusion complexes was much more rapid than AKF-PD alone. CONCLUSIONS: The formulation of AKF-PD/CDs inclusion complexes showed superior performance in improving dissolution properties of AKF-PD.
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