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  • Title: Probucol attenuates atrial structural remodeling in prolonged pacing-induced atrial fibrillation in dogs.
    Author: Li Y, Sheng L, Li W, Liu W, Gong Y, Xue H, Shan H.
    Journal: Biochem Biophys Res Commun; 2009 Apr 03; 381(2):198-203. PubMed ID: 19338773.
    Abstract:
    AIMS: Oxidative stress has recently been implicated in atrial fibrillation (AF); however, the mechanisms remain unclear. Herein, we hypothesize that probucol can attenuate atrial structure remodeling. METHODS: Twenty dogs were randomly divided into sham-operated, control, and probucol-treated groups. We identified apoptosis and histopathological changes in the atria. Oxidative stress was measured by lipid peroxidation and echocardiographic examinations were performed. RESULTS: Atrial apoptosis indexes were dramatically decreased in the probucol-treated group compared to the control group. Relative to the control group, the percentage of myolysis was dramatically decreased in the probucol-treated group (p < 0.01). There was less lipid peroxidation in the probucol-treated group than the control group. Atrial function was dramatically elevated in the probucol-treated group. CONCLUSIONS: The results of this study indicate that the antioxidant probucol suppresses atrial structural remodeling and may act as a new therapy for AF.
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