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  • Title: Appearance of hyperostosis frontalis interna in some osteoarcheological series from Hungary.
    Author: Hajdu T, Fóthi E, Bernert Z, Molnár E, Lovász G, Kovári I, Köhler K, Marcsik A.
    Journal: Homo; 2009; 60(3):185-205. PubMed ID: 19339004.
    Abstract:
    Hyperostosis frontalis interna (HFI) is a generalised pathological condition with an unknown etiology and variable clinical association. It is characterized by excess bone growth and manifested on the inner table of the frontal bone, occasionally extending onto the temporals, parietals and the occipital. The etiology of HFI is uncertain: it may be an unknown genetic predisposition, a common environmental exposure, or special metabolic diseases. The purpose of the present study is to report cases of HFI in some osteoarcheological series from Hungary and to emphasize the importance of the investigation of HFI in ancient populations. Twenty out of 803 adults with observable frontal bones exhibited HFI, ranging from early to mid-type, including 15 females and 5 males. Some overgrowths with edges were blending into the endocranial surface, and some were prominently protruding from the surface. Advanced cases of HFI (type C) were observed after age 40-60 years.
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