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  • Title: Usefulness of human telomerase reverse transcriptase in pancreatic juice as a biomarker of pancreatic malignancy.
    Author: Nakashima A, Murakami Y, Uemura K, Hayashidani Y, Sudo T, Hashimoto Y, Ohge H, Oda M, Sueda T, Hiyama E.
    Journal: Pancreas; 2009 Jul; 38(5):527-33. PubMed ID: 19342980.
    Abstract:
    OBJECTIVES: Human telomerase reverse transcriptase (hTERT), one of the subunits of telomerase, is a promising diagnostic marker for pancreatic cancer. In the present study, we did a large-scale analysis of 115 preoperative pancreatic juice specimens to evaluate the feasibility of detection of hTERT expression by immunohistochemistry for preoperative diagnosis of pancreatic malignancy. METHODS: The expression of hTERT was examined by immunohistochemistry in preoperative pancreatic juice samples. RESULTS: In pancreatic juice samples, hTERT expression was detectable in 84% of pancreatic ductal adenocarcinomas (PDACs), whereas 62% of PDACs were positive by cytology. In intraductal papillary mucinous neoplasms (IPMNs), hTERT expression was detectable in 88% of malignant IPMNs, whereas only 22% were positive by cytology. The sensitivity, specificity, and overall accuracy of hTERT expression for differentiation between carcinoma and other benign diseases were 85.1%, 82.1%, and 84.3%, respectively, whereas the same values for cytologic accuracy were 47.1%, 89.3%, and 57.4%, respectively. When the results of cytology and hTERT expression were combined, the sensitivity and overall accuracy increased to 92.0% and 87.8%, respectively. CONCLUSIONS: Our results suggested that the assessment of hTERT expression in preoperative pancreatic juice increased the sensitivity and accuracy of diagnosis of PDACs and malignant IPMNs without using special techniques.
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