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  • Title: Loss of vancomycin bactericidal activity against accessory gene regulator (agr) dysfunctional Staphylococcus aureus under conditions of high bacterial density.
    Author: Tsuji BT, Harigaya Y, Lesse AJ, Sakoulas G, Mylotte JM.
    Journal: Diagn Microbiol Infect Dis; 2009 Jun; 64(2):220-4. PubMed ID: 19345040.
    Abstract:
    The impact of accessory gene regulator (agr) dysfunction and high bacterial density on vancomycin killing and resistance was evaluated among 10 clinical methicillin-resistant Staphylococcus aureus bloodstream isolates using time kill experiments. Under conditions of high inocula and agr dysfunction, vancomycin activity was markedly attenuated, amplifying resistant mutants by 72 h.
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