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  • Title: Relationship between extracellular water fraction of total body water estimated by bioimpedance spectroscopy and cardiac troponin T in chronic haemodialysis patients.
    Author: Park J, Chung HC, Kim MS, Kim SJ, Chang JW, Lee JS.
    Journal: Blood Purif; 2009; 28(1):61-8. PubMed ID: 19346743.
    Abstract:
    BACKGROUND/AIMS: The ratio of extracellular water to total body water (ECW/TBW) estimated by bioimpedance spectroscopy (BIS) may be a useful volume index in haemodialysis (HD) patients, but its direct relation to cardiovascular (CV) outcomes has been rarely evaluated. METHODS: We investigated the relationship between ECW/TBW by BIS and cardiac troponin T (cTnT) level, a biochemical surrogate of CV mortality. RESULTS: Seventy-four HD patients without ischemic heart disease (age 51.6 +/- 13.2 years; male:female ratio 36:38; diabetes 37.8%) were recruited. Post-HD ECW/TBW was positively correlated to log cTnT levels (r = 0.60, p < 0.01). In multivariate regression models, male sex (beta = 0.23, p = 0.03), diabetes mellitus (beta = 0.21, p = 0.04), log high-sensitivity C-reactive protein (beta = 0.21, p = 0.04) and post-HD ECW/TBW (beta = 0.37, p < 0.01) were independent risk factors for elevated log cTnT levels. CONCLUSION: Post-HD ECW/TBW by BIS is worthy of further evaluation as a pathophysiological index for reducing CV mortality in HD patients.
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