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  • Title: Increased brain retention of Tc-99m HMPAO following acetazolamide administration.
    Author: Burt RW, Witt RM, Cikrit D, Carter J.
    Journal: Clin Nucl Med; 1991 Aug; 16(8):568-71. PubMed ID: 1934809.
    Abstract:
    Sixty-five patients referred for Tc-99m HMPAO SPECT brain perfusion studies had measurements of global Tc-99m HMPAO retention after injection at rest and after acetazolamide pretreatment. Acetazolamide produced relative changes in Tc-99m HMPAO retention similar to those previously reported with Xe-133 regional cerebral blood flow (rCBF) measurements. This addition to imaging protocols allows another objective evaluation of the cerebral vascular reserve.
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