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Title: Combinatorial chemistry in the agrosciences. Author: Lindell SD, Pattenden LC, Shannon J. Journal: Bioorg Med Chem; 2009 Jun 15; 17(12):4035-46. PubMed ID: 19349185. Abstract: Combinatorial chemistry and high throughput screening have had a profound effect upon the way in which agrochemical companies conduct their lead discovery research. The article reviews recent applications of combinatorial synthesis in the lead discovery process for new fungicides, herbicides and insecticides. The role and importance of bioavailability guidelines, natural products, privileged structures, virtual screening and X-ray crystallographic protein structures on the design of solid- and solution-phase compound libraries is discussed and illustrated.[Abstract] [Full Text] [Related] [New Search]