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  • Title: Relevance of red cell distribution width (RDW) in the differential diagnosis of microcytic anaemias.
    Author: Cesana BM, Maiolo AT, Gidiuli R, Damilano I, Massaro P, Polli EE.
    Journal: Clin Lab Haematol; 1991; 13(2):141-51. PubMed ID: 1934925.
    Abstract:
    The authors studied the red cell distribution width (RDW) index (obtained by Coulter Counter S Plus IV) in normal subjects and in patients with beta-thalassaemia trait and iron deficiency anaemia. Statistics and reference limits for the above three conditions are given. In order to make a differential diagnosis between beta-thalassaemia trait and iron deficiency anaemia, linear discriminant analysis was carried out. Global correct classification was 91.5% on our first sample of patients and 88.8% on a subsequent validation sample of microcytic patients. The percent of correct beta-thalassaemia trait diagnoses was 94.4% and 86.7% for the first and validation samples respectively. For iron deficiency anaemia correct diagnoses of 86.2% and 90.9% were achieved.
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