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  • Title: Type IV allergy to amide-type local anesthetics.
    Author: Klein CE, Gall H.
    Journal: Contact Dermatitis; 1991 Jul; 25(1):45-8. PubMed ID: 1935033.
    Abstract:
    The case of a 45-year-old woman is reported, who developed intense erythema and itching 1 day after subcutaneous (s.c.) injection of a local anesthetic containing mepivacaine and methylparaben. The reaction was attributed to a delayed-type sensitivity to mepivacaine, since mepivacaine gave a positive patch test response and also elicited a delayed sensitivity reaction after s.c. challenges, whereas prick and patch tests with methylparaben, as well as oral challenges, were negative. Interestingly, the patient also showed sensitization to lidocaine, a compound to which she had previously also been exposed.
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