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  • Title: [Genetic analysis of a complex chromosome rearrangement involving two chromosomes and four breakpoints in an azoospermic man].
    Author: Luo YQ, Shen M, Qian YL, Chen YL, Xu CM, Jin F.
    Journal: Zhonghua Yi Xue Yi Chuan Xue Za Zhi; 2009 Apr; 26(2):200-2. PubMed ID: 19350516.
    Abstract:
    OBJECTIVE: To perform genetic analysis of a complex chromosome rearrangement (CCR) 46,XY, t(3;11)(q27; q13), ins(11;3)(q13;p26p13) in an azoospermic man. METHODS: Peripheral blood lymphocytes we re obtained for karyotyping, and metaphases were studied by multicolor fluorescence in situ hybridization procedure, Y chromosomal microdeletions in the azoospermia factor (AZF) region were analyzed with multiplex polymerase chain reaction. RESULTS: The case was a complex chromosomal translocation between chromosomes 3 and 11 with four breakpoints, and accompanied with a band of chromosome 3 inserting into chromosome 11. No Y-chromosome microdeletions were identified at 6 STS sequences of the AZF loci. CONCLUSION: CCR can have a significant impact on male fertility. Molecular cytogenetic techniques may contribute to improving and personalizing reproductive counseling.
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