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  • Title: A pan-specific inhibitor of the polo-box domains of polo-like kinases arrests cancer cells in mitosis.
    Author: Reindl W, Yuan J, Krämer A, Strebhardt K, Berg T.
    Journal: Chembiochem; 2009 May 04; 10(7):1145-8. PubMed ID: 19350612.
    Abstract:
    Playing polo: Small-molecule inhibitors of polo-like kinase 1 are mostly ATP-competitive, and thus face enormous specificity hurdles. This communication explores the concept of inhibiting Plk1 with a small-molecule inhibitor of the protein-protein interactions required for Plk1 function.
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