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  • Title: [Obtaining and characteristics of domestic preparation interferon alpha-2b with prolonged effect].
    Author: Pokholenko IaA, Porubleva LV, Dubeĭ IIa, Rebriev AV, Sutugina LP, Gromovoĭ TIu, Pokrovskiĭ VA, Obolenskaia MIu, Chernykh SI.
    Journal: Ukr Biokhim Zh (1999); 2008; 80(6):92-100. PubMed ID: 19351063.
    Abstract:
    Pegylated interferon alpha-2b (PEG-IFN alpha-2b) is a domestic preparation of a modified recombinant interferon alpha-2b with prolonged effect. The preparation was obtained by N-terminal pegylation of IFN alpha-2b with polyethylene glycol (PEG). This paper presents the method of PEG-IFN alpha-2b synthesis and characteristics of the obtained product. PAAG electrophoresis, Western blot analysis and MALDI-TOF mass-spectrometry confirm that the preparation is an N-terminal pegylated IFN alpha-2b that contains no more than 10% of dipegylated IFN alpha-2b. The comparison of PEG-IFN alpha-2b with its foreign analogue has revealed the similarity of their biological activity and pharmacokinetic parameters.
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