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  • Title: Disruption of Chrysomya megacephala growth caused by lignan grandisin.
    Author: Nogueira CD, de Mello RP, Kato MJ, Cabral MM.
    Journal: J Med Entomol; 2009 Mar; 46(2):281-3. PubMed ID: 19351078.
    Abstract:
    The toxicity of tetrahydrofuran lignan grandisin was evaluated against larvae of Chrysomya megacephala F. (Diptera: Calliphoridae). The bioassay involved topical treatment on larvae, topical treatment on egg masses, and incorporation in the larval diet. Grandisin showed inhibition of postembryonic development by ovicidal (30%) and larvicidal (38%) effects and reduced larval weight (4 mg), when topically applied on egg masses and starving larvae (L1) at a concentration of 100 microg/microl. These findings elucidated the effect of grandisin on the C. megacephala life cycle and its potential to control C. megacephala populations.
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