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  • Title: Maternal celiac disease: improbable risk factor for neural tube defect.
    Author: de Almeida RC, Lima BO, Castro LC, Gandolfi L, Pratesi R.
    Journal: Eur J Gastroenterol Hepatol; 2009 Jul; 21(7):805-8. PubMed ID: 19352195.
    Abstract:
    OBJECTIVES: To verify the existence of possible relation between maternal celiac disease (CD) and the appearance of neural tube defects (NTD) in the newborn serological testing in 208 mothers with NTD-affected pregnancy were performed. METHODS: All sera were tested for total serum immunoglobulin A (IgA) levels and for IgA class endomysial antibody using indirect immunofluorescence technique. Participant age ranged from 19 to 43 years (mean: 33 years). None had been previously investigated for or had a family history of CD. RESULTS: Immunoglobulin levels were normal and results of the IgA-endomysial antibody tests were negative in all women tested. CONCLUSION: This study, although nonconclusive, did not corroborate earlier findings described in the literature of increased frequency of CD in mothers with a history of NTD-affected pregnancy. At this moment we feel that a routine screening for CD in pregnant women to avoid a possible pregnancy aggravated by NTD would not be justifiable.
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