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  • Title: Rhabdomyosarcoma associated hypertrophic osteoarthropathy in a child: detection by bone scintigraphy.
    Author: Garganese MC, De Sio L, Serra A, De Ioris MA, Bock C, Donfrancesco A, Ciofetta G.
    Journal: Clin Nucl Med; 2009 Mar; 34(3):155-7. PubMed ID: 19352278.
    Abstract:
    Hypertrophic osteoarthropathy (HOA) is characterized by digital clubbing, long bone periosteal reaction, and polyarthralgias. Primary familial HOA is very rare and is not associated with underlying disorders and has a good prognosis. Secondary pediatric nonneoplastic HOA is associated with cystic fibrosis, congenital heart disease, biliary atresia, and inflammatory bowel disease. Secondary neoplastic HOA may be associated with intra or extrathoracic tumors.A 5-year-old girl was admitted to our hospital for an abdominal mass, digital clubbing, and diffuse articular pain. The bone scan revealed symmetrical tracer uptake in the long bones. Upper and lower extremity x-rays were diagnostic for HOA. Paraneoplastic HOA in childhood accounts for not more than 12% of HOA paitents. HOA has been reported in 2 other cases of rhabdomyosarcoma.
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