These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Facile synthesis of 1,2,3,4-tetrahydro-beta-carbolines by one-pot domino three-component indole formation and nucleophilic cyclization.
    Author: Ohta Y, Oishi S, Fujii N, Ohno H.
    Journal: Org Lett; 2009 May 07; 11(9):1979-82. PubMed ID: 19354232.
    Abstract:
    Two direct synthetic methods of 1,2,3,4-tetrahydro-beta-carboline derivatives have been developed. After initial indole formation by copper-catalyzed domino three-component coupling-cyclization using an appropriate ethynylaniline, aldehyde, and a secondary amine, treatment with t-BuOK/hexane or MsOH afforded the desired tetrahydro-beta-carboline derivatives in moderate to good yields.
    [Abstract] [Full Text] [Related] [New Search]