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  • Title: Cytology and flow cytometry to identify ectopic thymic tissue masquerading as a thyroid nodule in two children.
    Author: Aguayo-Figueroa L, Golightly MG, Hu Y, Cohen HL, Wilson TA.
    Journal: Thyroid; 2009 Apr; 19(4):403-6. PubMed ID: 19355830.
    Abstract:
    BACKGROUND: Clinically unapparent thyroid nodules in children pose a significant problem in differential diagnosis and management. Ectopic thymic tissue in the thyroid gland is rare, but may masquerade as a thyroid nodule. This paper demonstrates the utility of flow cytometry as an adjunct to cytology by fine needle aspiration in diagnosing ectopic thymic tissue in the thyroid gland. SUMMARY: By demonstration of T lymphocytes maturing along two cell lineages and the absence of markers for malignant lesions, fine-needle aspiration, cytology, and flow cytometry were used to identify ectopic thymic tissue masquerading as a thyroid nodule in two children. CONCLUSION: Use of this technique prevented surgical intervention that otherwise would have been necessary to obtain an accurate diagnosis of these thyroid nodules.
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