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  • Title: Studies of bioactivity, conformation and pharmacokinetic profiles of site-specific PEGylated thymosin alpha 1 derivatives.
    Author: Qie J, Ma J, Wang L, Xu X, Zheng J, Dong S, Xie J, Sun H, Zhou W, Qi C, Zhao X, Zhang Y, Liu K.
    Journal: Drug Metab Lett; 2007 Aug; 1(3):232-40. PubMed ID: 19356048.
    Abstract:
    Site-specific mono-PEGylations were performed in different conformational regions of Thymosin alpha 1 (T alpha 1) by introducing one cysteine residue into the chosen site and coupling with thiol-specific mPEG-MAL reagent. Results demonstrated that PEGylated sites and regions influenced the conformations and pharmacokinetic profiles of the peptide greatly with following order: alpha-helix, beta-turn, random coil and terminals, but little on the immunoactivity.
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