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  • Title: Childbirth moderates the genetic and environmental influences on BMI in adult twins.
    Author: Rebollo-Mesa I, Ordoñana JR.
    Journal: Obesity (Silver Spring); 2009 Aug; 17(8):1646-7. PubMed ID: 19360010.
    Abstract:
    We report a study of the moderating role that the number of childbirths has on the genetic and environmental influences on BMI variation. We used a classical twin design with a sample of 704 adult female twins (334 monozygotic and 370 dizygotic). A gene-environment interaction (G x E) model was applied to estimate the moderating effects of childbearing. Results show that age and number of children exert a significant positive main effect on BMI. Furthermore, we found significant moderating effects of childbearing, with a larger number of children associated with an increased sensitivity to environmental factors.
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