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  • Title: Retention data from reverse-phase high-performance thin-layer chromatography in characterization of some bis-salicylic acid derivatives.
    Author: Djaković-Sekulić T, Perisić-Janjić N, Djurendi E.
    Journal: Biomed Chromatogr; 2009 Aug; 23(8):881-7. PubMed ID: 19360764.
    Abstract:
    The chromatographic behaviour of salicylic acid derivatives was investigated using reversed-phase high performance thin-layer chromatography (RP HPTLC) with methanol-water and dioxane-water binary mixtures as mobile phase in order to establish relationships between chromatographic data and selected physico-chemical parameters that are related to ADME (absorption, distribution, metabolism and elimination). Some of the investigated compounds were screened for antioxidant activity. Examination of chromatographic behaviour revealed a linear correlation between R(M) values and the volume fraction of mobile phase modifier. Obtained R(M)(0) values were correlated with lipophilicity, solubility, human intestinal absorption, plasma-protein binding, and blood-brain barrier data. The comparison among chromatographic data obtained by two mobile phase was performed with a statistical technique, principle component analysis.
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