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  • Title: Hypolipidemic activity of 18beta-glycyrrhetinic acid on streptozotocin-induced diabetic rats.
    Author: Kalaiarasi P, Kaviarasan K, Pugalendi KV.
    Journal: Eur J Pharmacol; 2009 Jun 10; 612(1-3):93-7. PubMed ID: 19361497.
    Abstract:
    Diabetes mellitus is a significant risk factor for cardiovascular complications. This study was undertaken to investigate the effect of 18beta-glycyrrhetinic acid on plasma glucose and plasma and tissue lipid profiles in streptozotocin-induced diabetic rats. Diabetes was induced in adult male albino rats of the Wistar strain, weighing 180-200 g, by administration of streptozotocin (40 mg/kg of body weight) intraperitoneally. Rats were randomly divided into seven groups. Group I: control animals (normal, nondiabetic animals), Group II: 18beta-glycyrrhetinic acid control, Group III: streptozotocin-diabetic, untreated animals; Groups IV, V and VI: streptozotocin-diabetic animals given 50, 100 and 200 mg 18beta-glycyrrhetinic acid, and Group VII: streptozotocin-diabetic animals given glibenclamide. The levels of total cholesterol, triglycerides, free fatty acids, and phospholipids, were assayed in the plasma besides lipoprotein-cholesterol (high density lipoprotein-cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL-C) and very low density lipoprotein-cholesterol (VLDL-C)) and tissues (liver, kidney and heart). Total cholesterol, triglyceride, free fatty acid, and phospholipid (LDL-C and VLDL-C in plasma only) levels increased in plasma and tissues significantly, while plasma HDL-cholesterol significantly decreased in diabetic rats. Treatment with 18beta-glycyrrhetinic acid prevented the above changes and improved towards normalcy. Thus administration of 18beta-glycyrrhetinic acid is able to reduce hyperglycemia and hyperlipidemia related to the risk of diabetes mellitus.
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