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  • Title: 1,8-Naphthyridine-3-carboxamide derivatives with anticancer and anti-inflammatory activity.
    Author: Kumar V, Jaggi M, Singh AT, Madaan A, Sanna V, Singh P, Sharma PK, Irchhaiya R, Burman AC.
    Journal: Eur J Med Chem; 2009 Aug; 44(8):3356-62. PubMed ID: 19361894.
    Abstract:
    A number of 1-propargyl-1,8-naphthyridine-3-carboxamide derivatives (15-35) have been synthesized and screened for their in vitro cytotoxicity and anti-inflammatory activity. Compounds 22, 31 and 34 have shown high cytotoxicity against a number of cancer cell lines, while compound 24 showed significant anti-inflammatory activity.
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