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  • Title: Quaternary ammonium N,N-dichloroamines as topical, antimicrobial agents.
    Author: Francavilla C, Low E, Nair S, Kim B, Shiau TP, Debabov D, Celeri C, Alvarez N, Houchin A, Xu P, Najafi R, Jain R.
    Journal: Bioorg Med Chem Lett; 2009 May 15; 19(10):2731-4. PubMed ID: 19362467.
    Abstract:
    A series of backbone modified and sulfonic acid replacement analogs of our topical, clinical candidate (iii) were synthesized. Their antimicrobial activities and aqueous stabilities at pH 4 and pH 7 were determined, and has led us to identify quaternary ammonium N,N-dichloroamines as a new class of topical antimicrobial agents.
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