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  • Title: Protective effects of a benzoxazine derivative against oxidized LDL-induced apoptosis and the increases of integrin beta4, ROS, NF-kappaB and P53 in human umbilical vein endothelial cells.
    Author: Liu X, Zhao J, Xu J, Zhao B, Zhang Y, Zhang S, Miao J.
    Journal: Bioorg Med Chem Lett; 2009 May 15; 19(10):2896-900. PubMed ID: 19362839.
    Abstract:
    To investigate whether 6-amino-2,3-dihydro-3-hydroxymethyl-1,4-benzoxazine (ABO) inhibits oxidized low-density lipoprotein (oxLDL)-induced human umbilical vein endothelial cell (HUVEC) apoptosis, we treated HUVECs with oxLDL in the absence or presence of ABO. The results showed that ABO could act as an effective inhibitor of oxLDL-elicited HUVEC apoptosis by inhibiting the levels of integrin beta4, reactive oxygen species (ROS), NF-kappaB and P53, and suppressing NF-kappaB nuclear translocation.
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