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  • Title: Prophylactic effect of administration of human gamma globulins in a mouse model of tuberculosis.
    Author: Olivares N, Puig A, Aguilar D, Moya A, Cádiz A, Otero O, Izquierdo L, Falero G, Solis RL, Orozco H, Sarmiento ME, Norazmi MN, Hernández-Pando R, Acosta A.
    Journal: Tuberculosis (Edinb); 2009 May; 89(3):218-20. PubMed ID: 19362883.
    Abstract:
    The protective effect of human gamma globulins on Mycobacterium tuberculosis infection was evaluated in a mouse model of intratracheal infection. Animals receiving human gamma globulins intranasally, 2h before intratracheal challenge showed a significant decrease in lung bacilli load compared to non-treated animals in different time intervals of up to 2 months after challenge. The same effect was obtained when M. tuberculosis was pre-incubated with the gamma globulin before challenge. The protective effect of the gamma-globulin formulation was abolished after pre-incubation with M. tuberculosis. These results suggest a potential role of specific antibodies in the defence against mycobacterial infections.
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