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  • Title: Role of GerKB in germination and outgrowth of Clostridium perfringens spores.
    Author: Paredes-Sabja D, Setlow P, Sarker MR.
    Journal: Appl Environ Microbiol; 2009 Jun; 75(11):3813-7. PubMed ID: 19363077.
    Abstract:
    Previous work indicated that Clostridium perfringens gerKA gerKC spores germinate significantly, suggesting that gerKB also has a role in C. perfringens spore germination. We now find that (i) gerKB was expressed only during sporulation, likely in the forespore; (ii) gerKB spores germinated like wild-type spores with nonnutrient germinants and with high concentrations of nutrients but more slowly with low nutrient concentrations; and (iii) gerKB spores had lower colony-forming efficiency and slower outgrowth than wild-type spores. These results suggest that GerKB plays an auxiliary role in spore germination under some conditions and is required for normal spore viability and outgrowth.
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