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  • Title: Synthesis of isoxazolo[5,4-b]pyridines by microwave-assisted multi-component reactions in water.
    Author: Tu SJ, Zhang XH, Han ZG, Cao XD, Wu SS, Yan S, Hao WJ, Zhang G, Ma N.
    Journal: J Comb Chem; 2009; 11(3):428-32. PubMed ID: 19364093.
    Abstract:
    A series of new polycyclic-fused isoxazolo[5,4-b]pyridines were obtained by a one-pot tandem reaction under microwave irradiation in water. Without any use of additional reagent or catalyst, the synthetic protocol represents a green one and makes this methodology suitable for library synthesis in drug discovery efforts.
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