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  • Title: [The value of intraoperative frozen section in surgical management of thyroid nodules. Report of 409 cases].
    Author: Farah-Klibi F, Blel A, Neji O, Ferjaoui M, Ben Jilani S, Zermani R.
    Journal: Ann Pathol; 2009 Apr; 29(2):80-5. PubMed ID: 19364577.
    Abstract:
    OBJECTIVE: The purpose of this study was to assess the value of intraoperative frozen section diagnosis in thyroid surgery and determine its limitations. METHODS: This retrospective study examined the results of 409 frozen sections of thyroid specimens analyzed over the 4-year period and their correlations with the final histological examination. RESULTS: In our series, frozen section diagnosis was concordant with subsequent histopathological examination in 96.6% of cases, discordant in 3.4%. All discordances were due to false-negative diagnoses. Non-false-positive result was found. The global specificity of frozen section analysis for all histological subtypes was 100% and its sensitivity was 68.2%. CONCLUSION: The frozen section evaluation of thyroid neoplasm is highly accurate and specific. A high degree of specificity with an acceptable sensitivity is requested. However, the frozen section examination has still some limits in the diagnosis of microfollicular lesions.
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