These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Positioning of 99mTc-chelators influences radiolabeling, stability and biodistribution of Affibody molecules.
    Author: Ekblad T, Orlova A, Feldwisch J, Wennborg A, Karlström AE, Tolmachev V.
    Journal: Bioorg Med Chem Lett; 2009 Jul 15; 19(14):3912-4. PubMed ID: 19364646.
    Abstract:
    Affibody molecules represent a novel class of affinity proteins with a high potential as tracers for radionuclide molecular imaging. In this comparative structure-property study, a series of Affibody molecules with the (99m)Tc-chelators maGGG, maSSS, or maESE attached to the epsilon-amine of the internally positioned K49 was prepared by peptide synthesis, for comparison to molecules with similar chelators positioned at the N-terminus. The conjugates were labeled with (99m)Tc and evaluated in vitro and in vivo. It was found that both composition and position of the chelating moiety influence the label stability, biodistribution and targeting properties of HER2-binding Affibody molecules.
    [Abstract] [Full Text] [Related] [New Search]