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  • Title: Addition of carbon-based nucleophiles to Fmoc-protected acyl iminium ions.
    Author: Hartman AE, Brophy CL, Cupp JA, Hodge DK, Peelen TJ.
    Journal: J Org Chem; 2009 May 15; 74(10):3952-4. PubMed ID: 19366203.
    Abstract:
    Weakly basic carbon nucleophiles add efficiently to a Fmoc-protected N,O-acetal compound. The new reactions highlight the compatibility of the Fmoc protecting group with moderately basic reaction conditions and should serve as a model for the development of more efficient syntheses of Fmoc-protected amino acids.
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