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  • Title: Primary mediastinal large B-cell lymphoma.
    Author: Faris JE, LaCasce AS.
    Journal: Clin Adv Hematol Oncol; 2009 Feb; 7(2):125-33. PubMed ID: 19367254.
    Abstract:
    Primary mediastinal large B-cell lymphoma is a subtype of diffuse large B-cell lymphoma, which has distinct clinical and molecular features, many of which are similar to that of nodular sclerosing/classical Hodgkin lymphoma. Anthracycline-based chemotherapy forms the foundation for treatment of this lymphoma. This review will discuss controversial topics that warrant further study, such as the superiority of third generation regimens over CHOP-based regimens (cyclophosphamide, doxorubicin, vincristine, and prednisone), the use of involved field radiotherapy, and the assessment of clinical response by positron emission tomography scans.
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