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  • Title: Cognitive enhancement by SGS742 in OF1 mice is linked to specific hippocampal protein expression.
    Author: Sunyer B, Diao WF, Kang SU, An G, Boddul S, Lubec G.
    Journal: J Proteome Res; 2008 Dec; 7(12):5237-53. PubMed ID: 19367722.
    Abstract:
    Cognitive enhancement by the GABA (B) antagonist SGS742 has been reported and we decided to search for proteins involved. Hippocampi from OF1 mice were from SGS742- treated animals and three control groups. Proteins were extracted and run on 2DE, and spots were quantified. Significantly different protein spots were identified by two mass spectrometry principles, nano-LC-ESI-MS/MS and by nano-LC-ESI(CID/ETD)-MS/MS. Signaling, chaperone and metabolic enzyme proteins were linked to memory enhancement.
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