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  • Title: The changing face of febrile neutropenia-from monotherapy to moulds to mucositis. Why empirical therapy?
    Author: Klastersky J.
    Journal: J Antimicrob Chemother; 2009 May; 63 Suppl 1():i14-5. PubMed ID: 19372173.
    Abstract:
    Why empirical therapy? Because it works! Empirical antimicrobial therapy is a reasonable, pragmatic approach to limit the ominous threat of Gram-negative sepsis in febrile neutropenic cancer patients. Empirical treatment of occult fungal infection in patients with neutropenia and persistent fever, in spite of initial broad-spectrum antimicrobial coverage, is effective but the role of pre-emptive treatment remains to be established.
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