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  • Title: Anticataractogenic effect of an extract of the oyster mushroom, Pleurotus ostreatus, in an experimental animal model.
    Author: Isai M, Elanchezhian R, Sakthivel M, Chinnakkaruppan A, Rajamohan M, Jesudasan CN, Thomas PA, Geraldine P.
    Journal: Curr Eye Res; 2009 Apr; 34(4):264-73. PubMed ID: 19373574.
    Abstract:
    PURPOSE: To evaluate the efficacy of Pleurotus ostreatus extract in preventing selenite-induced cataractogenesis. METHODS: In vitro, enucleated rat lenses, divided into one control and three experimental groups (selenite only, simultaneous selenite and extract, initial extract and subsequent selenite), underwent morphological and biochemical evaluation. The anti-cataractogenic effect was also evaluated in vivo. RESULTS: In vitro, simultaneous incubation of extract with selenite-challenged lenses caused a decrease in lens opacification by maintaining antioxidant components at near normal levels. In vivo, P.ostreatus (300 mg/kg body weight) prevented cataract in 75% of rats. CONCLUSION: Extract of P. ostreatus prevents experimental selenite-induced cataractogenesis.
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