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  • Title: Outcome of surgical management of bisphosphonate-related osteonecrosis of the jaws: review of 33 surgical cases.
    Author: Stanton DC, Balasanian E.
    Journal: J Oral Maxillofac Surg; 2009 May; 67(5):943-50. PubMed ID: 19375001.
    Abstract:
    PURPOSE: We describe our experience with surgical management of bisphosphonate-related osteonecrosis of the jaws (BRONJ). MATERIALS AND METHODS: The data included 33 BRONJ cases treated surgically by a single surgeon at the Hospital of the University of Pennsylvania. RESULTS: Of the 30 debridement patients, 25 (including 1 sequestrectomy patient who required formal debridement) healed completely. Of the 30 patients who underwent surgical debridement, 18 healed following this initial treatment and remained healed. Of the 4 patients requiring sequestrectomy, 3 healed after the initial treatment. Thus, 28 of 33 patients healed completely with complete mucosal coverage and elimination of pain. Four patients developed occurrence of BRONJ at a separate site. All 4 patients were treated with our surgery protocol and remain healed. Thus, 32 of 37 BRONJ occurrences have healed with our surgical debridement protocol or sequestrectomy. The follow-up range was 1 to 40 months (average 10.7). CONCLUSIONS: The results of our case series have shown that surgical debridement can be successful in treating BRONJ.
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