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  • Title: Nuclease resistant methylphosphonate-DNA/LNA chimeric oligonucleotides.
    Author: Nagahama K, Veedu RN, Wengel J.
    Journal: Bioorg Med Chem Lett; 2009 May 15; 19(10):2707-9. PubMed ID: 19375912.
    Abstract:
    Synthesis of chimeric 9-mer oligonucleotides containing methylphosphonate-linkages and locked nucleic acid (LNA) monomers, their binding affinity towards complementary DNA and RNA, and their 3'-exonucleolytic stability are described. The obtained methylphosphonate-DNA/LNA chimeric oligonucleotides display similarly high RNA affinity and RNA selectivity as a corresponding 9-mer DNA/LNA chimeric oligonucleotide, but much higher resistance towards 3'-exonucleolytic degradation.
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