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  • Title: Spatial regulation of specific gene expression through photoactivation of RNAi.
    Author: Endoh T, Sisido M, Ohtsuki T.
    Journal: J Control Release; 2009 Aug 04; 137(3):241-5. PubMed ID: 19376174.
    Abstract:
    In this study we describe the spatial regulation of RNA interference (RNAi) using an RNA-carrier protein labeled with a fluorescent dye and a light source to trigger the RNAi. We demonstrate photo-dependent gene silencing using several dyes with different excitation wavelengths. Additionally, we use light from a halogen lamp and a photomask to produce photopatterned RNAi, and laser light to trigger single-cell RNAi on cell culture plates.
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