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  • Title: Role of purines on hepatic ischemia-reperfusion lesions in rabbit.
    Author: Taha MO, Simões MJ, Mendonça MV, Lugo FR, Carmo-Filho R, Lazarini JL, Bessa MZ, Marconi TD, Magalhães KG, Soares JH, Tersariol IL, Monteiro HP, Oliveira-Júnior IS, Jurkiewicz A, Caricati-Neto A.
    Journal: Transplant Proc; 2009 Apr; 41(3):807-11. PubMed ID: 19376358.
    Abstract:
    In this work, we evaluate the effects of adenosine 5' triphosphate (ATP) on hepatic lesions caused by ischemia/reperfusion (I/R) in liver rabbit. Rabbits were pretreated with ATP (15 mg/kg IV) or saline solution 0.9% (SS), before the hepatic I/R procedure. We evaluated the effects of ATP on hepatic injury before and after I/R. The warm hepatic I/R procedure caused profound acute liver injury, as indicated by elevated serum aspartate aminotransferase, alanine aminotransferase, and lactic dehydrogenase levels, as well as a high apoptotic cell count. All these changes were attenuate by ATP treatment before the hepatic I/R procedure. These results suggested that ATP exerted protective effects on hepatic I/R lesions in the rabbit. This ATP effect may be related to improved energy metabolism during reperfusion in ischemic livers protecting against functional damage of cellular and subcellular membranes during lipid peroxidation.
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