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  • Title: Effects of allopurinol on ischemia and reperfusion in rabbit livers.
    Author: Taha MO, Simões MJ, Noguerol EC, Mendonça FP, Pascoalick HM, Alves RA, Vivian ME, Morales FP, Campos AC, Magalhães KG, Venerando PS, Tersariol IL, Monteiro HP, Oliveira-Júnior IS, Jurkiewicz A, Caricati-Neto A.
    Journal: Transplant Proc; 2009 Apr; 41(3):820-3. PubMed ID: 19376361.
    Abstract:
    In this work, we evaluated the effects of allopurinol (ALO), an inhibitor of xanthine oxidase (XO), on hepatic lesions caused by ischemia/reperfusion (I/R) in the rabbit liver. Rabbits were pretreated with ALO (10 mg/kg IV) or saline solution 0.9% before the hepatic I/R procedure. The effects of ALO on hepatic injury were evaluated before and after I/R. A standard, warm hepatic I/R procedure caused profound acute liver injury, as indicated by elevated serum aspartate aminotransferase, alanine aminotransferase, and lactic dehydrogenase levels, as well as a high apoptotic cell count. All of these changes were reversed by the administration of ALO before the hepatic I/R procedure. In conclusion, ALO exerted protective effects on hepatic I/R lesions. This protective effect of ALO was probably associated with blocking the generation of superoxide anions during the hepatic I/R procedure by inhibiting XO activity.
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