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  • Title: Selective G-quadruplex ligands: the significant role of side chain charge density in a series of perylene derivatives.
    Author: Micheli E, Lombardo CM, D'Ambrosio D, Franceschin M, Neidle S, Savino M.
    Journal: Bioorg Med Chem Lett; 2009 Jul 15; 19(14):3903-8. PubMed ID: 19376705.
    Abstract:
    The human telomeric G-quadruplex structure is a promising target for the design of cancer drugs. The selectivity of G-quadruplex ligands with respect to duplex genomic DNA is of especial importance. The high selectivity of polyamine conjugated perylene derivatives appears to be regulated by side-chain charge density, as indicated by data from a FRET melting assay and induced CD spectroscopy.
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