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  • Title: Synthesis, antiplatelet and in silico evaluations of novel N-substituted-phenylamino-5-methyl-1H-1,2,3-triazole-4-carbohydrazides.
    Author: Jordão AK, Ferreira VF, Lima ES, de Souza MC, Carlos EC, Castro HC, Geraldo RB, Rodrigues CR, Almeida MC, Cunha AC.
    Journal: Bioorg Med Chem; 2009 May 15; 17(10):3713-9. PubMed ID: 19380229.
    Abstract:
    This paper describes the synthesis, antiplatelet and theoretical evaluations of 10 N-substituted-phenylamino-5-methyl-1H-1,2,3-triazole-4-carbohydrazides (2a-j). These compounds were synthesized, characterized and screened for their in vitro antiplatelet profile against human platelet aggregation using arachidonic acid, adrenaline and ADP as agonists. Among NAH derivatives 2a-j, the compounds 2a, 2c, 2e, 2g and 2h were the most promising molecules with significant antiplatelet activity.
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