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  • Title: [A case of metastatic breast cancer resistant to anastrozole treatment responding to high-dose toremifene].
    Author: Murata T, Yoshino H, Bandou H, Morita K, Kurokawa M, Inaki N, Kotake M, Kadoya S, Yamamoto M, Takayanagi T, Yamada T.
    Journal: Gan To Kagaku Ryoho; 2009 Apr; 36(4):671-3. PubMed ID: 19381046.
    Abstract:
    The patient was a 56-year-old female. At the age of 35 years, she had under gone left mastectomy and axillary lymph node dissection for breast cancer. After surgery, hormonal therapy was continued for 3 years. Then, no treatment was performed. In this study, single therapy with an AI agent was started to treatbilateral supraclavicular fossa/mediastinal lymphnode metastases. After 6 months, a partial response(PR)was achieved. However, progression of the disease(PD)was noted after 1 year. Thereafter,the regimen was switched to single high-dose(120mg/day)TOR therapy. CT revealed the disappearance of the bilateral supraclavicular fossa lymphnodes and a marked reduction of the other lymphnodes. Currently, the patient is being treated, with an interval of 10 months from the start of TOR therapy.
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