These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Protocol conversion from a calcineurin inhibitor based therapy to sirolimus.
    Author: Oberbauer R.
    Journal: Transplantation; 2009 Apr 27; 87(8 Suppl):S7-10. PubMed ID: 19384186.
    Abstract:
    Small late-conversion studies found an impressive glomerular filtration rate (GFR) increase 1 year after conversion from calcineurin inhibitor (CNI) to sirolimus (SRL). This effect could not be detected in the considerably larger CONVERT study, which found a lower rate of malignancies in the SRL group. In the spare the nephron trial patients converted to SRL exhibited a mean measured GFR of 68 mL/min at 1 year compared with 60 mL/min from CNI patients (P<0.05). Accordingly, the CONCEPT study which randomized patients to SRL conversion 3 months after transplantation reported a significant higher GFR in the SRL patients at 1 year. These trials showed that conversion of stable renal transplant recipients from CNI to SRL is safe.
    [Abstract] [Full Text] [Related] [New Search]