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  • Title: Lymph node involvement in ampullary cancer: the importance of the number, ratio, and location of metastatic nodes.
    Author: Sierzega M, Nowak K, Kulig J, Matyja A, Nowak W, Popiela T.
    Journal: J Surg Oncol; 2009 Jul 01; 100(1):19-24. PubMed ID: 19384907.
    Abstract:
    BACKGROUND AND OBJECTIVES: Lymph node involvement significantly affects survival of cancer patients. The aim of this study was to evaluate the importance of the number, ratio, and location of metastatic lymph nodes in ampullary cancers. METHODS: Medical records of 111 patients who underwent curative pancreaticoduodenectomy for ampullary carcinomas were reviewed. RESULTS: Metastatic lymph nodes were found in 52 (47%) patients and the median number of involved nodes was 3 (95% confidence interval (CI) 3-4; range 1-17). In the univariate analysis, gender, type of pancreaticoduodenectomy, depth of tumor invasion, perineural invasion, presence of metastatic nodes, their number, and ratio of metastatic nodes significantly correlated with patient survival. However, the location of metastatic nodes did not influence survival among patients with nodal involvement. Only four or more metastatic nodes (relative risk 7.35, 95% CI 3.34-16.17) and tumor invasion of peripancreatic soft tissues (relative risk 5.00, 95% CI 1.20-20.92) were the independent prognostic factors in the multivariate analysis. CONCLUSIONS: The number of metastatic nodes significantly affected patient survival. Although the location and ratio of metastatic nodes were not independent prognostic factors, these variables should be further evaluated with large-scale population data sets.
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