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  • Title: Treatment of HIV infection with raltegravir.
    Author: Chirch LM, Morrison S, Steigbigel RT.
    Journal: Expert Opin Pharmacother; 2009 May; 10(7):1203-11. PubMed ID: 19385721.
    Abstract:
    BACKGROUND: Raltegravir, an inhibitor of the HIV-1 integrase enzyme, is now available for the treatment of drug-resistant virus. OBJECTIVE: To establish raltegravir as an effective addition to the existing antiretroviral armamentarium by reviewing pharmacokinetics, efficacy, safety and tolerability. METHODS: Data from pharmacokinetic, Phase II and III clinical trials were reviewed. RESULTS/CONCLUSIONS: Results from clinical trials indicate that raltegravir is safe and highly effective in the treatment of both antiretroviral-naïve and -experienced patients.
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