These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: "Signal-on" detection of DNA hole transfer at the single molecule level.
    Author: Takada T, Takeda Y, Fujitsuka M, Majima T.
    Journal: J Am Chem Soc; 2009 May 20; 131(19):6656-7. PubMed ID: 19388695.
    Abstract:
    The DNA base stack provides unique features for the efficient long-range charge transfer. For the purpose of investigating the hole transfer process of individual DNA and the optical readout of DNA information at the single molecule level, we performed single-molecule detection of DNA hole transfer (DNA HT) using single-molecule fluorescence spectroscopy. We have established the single-molecule detection of DNA HT at the single molecule level based on the fluorescence generation by combining the oxidative reaction of the quencher molecule through DNA HT and the cancellation of FRET. This "signal-on" detection system makes it possible to detect DNA HT in individual DNA and the base-pair mismatch in the target DNA with high sensitivity and accuracy.
    [Abstract] [Full Text] [Related] [New Search]