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  • Title: Topical treatment of toxic epidermal necrolysis with Iodoplex.
    Author: Kaufman T, Shechter H, Bar-Joseph G, Hirshowitz B.
    Journal: J Burn Care Rehabil; 1991; 12(4):346-8. PubMed ID: 1939307.
    Abstract:
    Toxic epidermal necrolysis (TEN) is characterized by extensive exfoliation of the epidermis, mucosal ulcerations and fever, after a recent intake of a new drug. TEN developed in an 8-year-old girl after she ingested sulfonamides and sustained skin injuries of 90% total body surface area. In addition to her critical care management, local treatment consisted of Iodoplex cream (Biosearch Laboratories, Haifa, Israel), a long-acting antimicrobial agent from which iodine is slowly released over 48 hours. Healing was observed within 8 to 17 days after initial application. Iodoplex cream is an additional topical agent for the local treatment of TEN when porcine heterografts or allografts might not be feasible.
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